MitoDat - Mendelian Inheritance and the Mitochondrion

Notes on MitoDat icon image. Rat brain dendrite illustrating 6 mitochondria. Courtesy of Dr. M. Brightman and L. Chang. NINDS, NIH.

• Description of the database
• Search The Mitochondrion Database
• How to download The Mitochondrion Database
• Database editors
• Chromosome idiograms

• MigDB - The Mitochondria Interest Group

  This database is dedicated to the nuclear genes specifying the enzymes, structural proteins, and other proteins, many still not identified, involved in mitochondrial biogenesis and function. MitoDat highlights predominantly human nuclear-encoded mitochondrial proteins, although we are including proteins from other animals in addition to those currently known only from yeast and other fungal mitochondria, as well as from plant mitochondria. The database consolidates information from various biological databases, eg., GenBank, SwissPro, Genome Data Base (GDB), Online Mendelian Inheritance in Man (OMIM), et al. Because the mitochondrion has a central role in cellular metabolism, it is involved in many human diseases. This database should help us in studying these diseases. We are also hyperlinked to the Report of the committee on human mitochondrial DNA, maintained by the Wallace group at Emory http://infinity.gen.emory.edu/mitomap.html. It can be accessed here and also from the results when searching mitoDat for mitochondrially encoded genes. The Report of the committee on human mitochondrial DNA is currently the most comprehensive source of information on mitochondrial DNA mutations, other defects, and disorders in which the mitochondrial DNA deficiencies have been associated.

  Search The Mitochondrion Database

  The database may be searched to find entries matching a key phrases in any of the data for that entry.
  • Search the Mitochondrion database by specifying search terms below (one per entry). Each Mitochondrial entry is searched for the conjunction (i.e. AND) or disjunction (i.e. OR) of the terms. [Note terms may be any part of a database entry but may not include any spaces.]
    
    also report references (rather than just ref. id#s)
    Present results as a table
    Enter search terms (you may use either AND or OR term connectives):
    

    Alternatively, you can select onechromosome number to search on from the scrollable menu below.

    Chromosome number:
    Chromosome 01 Chromosome 02 Chromosome 03 Chromosome 04 Chromosome 05 Chromosome 06 Chromosome 07 Chromosome 08 Chromosome 09 Chromosome 10 Chromosome 11 Chromosome 12 Chromosome 13 Chromosome 14 Chromosome 15 Chromosome 16 Chromosome 17 Chromosome 18 Chromosome 19 Chromosome 20 Chromosome 21 Chromosome 22 Chromosome X Chromosome Y

  • Database definitions
  • Notes on the database
  • Get entry by EC number

  Hint: you can restrict the search by specifying the Organelle Compartment name with an AND restriction. The current compartments are:
  

  1. Outer membrane
  2. Intermembrane space
  3. Inner membrane
  4. Matrix

  Then, a search string might be:

         NADH2 and Outer and membrane
  
  Note: use "Outer and membrane" - not "Outer membrane". The
  "AND" is required because of the space. Search is case-independent.
  [Note: currently you can use either all AND connectives or all OR
  connectives - but not both.]  

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  How to Download The Mitochondrion Database

  1. In the Web browser (eg. Mosaic) viewer under Options, turn on Load to Local Disk.
  2. Click on to download database file
  3. Click on to download references file
  4. [Remember to turn off Load to Local Disk.]

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